Animal Models in Diabetes Research by Hans-Georg Joost, Hadi Al-Hasani, Annette Schürmann

By Hans-Georg Joost, Hadi Al-Hasani, Annette Schürmann

Detailing the newest protocols for studying animal versions of diabetes, particularly resistant teams of rodents corresponding to the NOD mouse, and together with specialist suggestion on implementation, it is a necessary new quantity within the tools in Molecular Biology sequence.

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Kidney Int 74:1610–1616 Wong DW et al (2007) Loss of angiotensinconverting enzyme-2 (Ace2) accelerates diabetic kidney injury. Am J Pathol 171:438–451 Oudit GY et al (2010) Human recombinant ACE2 reduces the progression of diabetic nephropathy. Diabetes 59:529–538 Poplawski MM et al (2011) Reversal of diabetic nephropathy by a ketogenic diet. PLoS One 6:e18604 Al-Khalifa A et al (2009) Therapeutic role of low-carbohydrate ketogenic diet in diabetes. Nutrition 25:1177–1185 Badman MK et al (2009) A very low carbohydrate ketogenic diet improves glucose tolerance in ob/ob mice independent of weight loss.

To address this hypothesis, Poplawski and coworkers examined if a ketogenic diet can reverse DN in C57BL/6 Akita mice (39). After the development of DN had been confirmed in the Akita mice at 20 weeks of age by the presence of tenfold increase in albuminuria, half of the Akita mice and half of the nondiabetic controls were placed on a ketogenic diet while the remaining animals were maintained on a standard high-carbohydrate diet. Ketogenic diet increased blood 3-OHB level, and after 2 months on the diet, both blood glucose level as well as urinary albumin excretion was completely normalized in diabetic Akita mice without insulin treatment.

Duka I et al (2001) Vasoactive potential of the b(1) bradykinin receptor in normotension and hypertension. Circ Res 88:275–281 25. Futrakul N et al (2006) Early detection of endothelial injury and dysfunction in conjunction with correction of hemodynamic maladjustment can effectively restore renal function 2 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. in type 2 diabetic nephropathy. Clin Hemorheol Microcirc 34:373–381 Ignarro LJ et al (1987) Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

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