Advances in Research on Neurodegeneration: Volume 6 by Margot Mayer-Pröschel (auth.), Prof. Dr. W. Poewe, Dr. G.

By Margot Mayer-Pröschel (auth.), Prof. Dr. W. Poewe, Dr. G. Ransmayr (eds.)

The booklet includes unique articles and reports awarded on the sixth overseas wintry weather convention on Neurodegeneration, held from November 20–23, 1997 in Kitzbuhel/Austria. the purpose of this convention used to be to provide and talk about contemporary information at the interface among neuroimmunology and neurodegeneration, specifically susceptibility to autoimmune and neurodegenerative tactics, neuroprotection and restorative therapy thoughts. those matters have been mentioned within the mild of modern advancements in a number of sclerosis, Parkinson’s affliction, amyotrophic lateral sclerosis, Huntington’s illness and multisystem atrophy. The articles spotlight subject matters, that are fairly attention-grabbing for the clinician and the neuroscientist. many of the neuroprotective recommendations have already been constructed or are at this time clinically investigated. The neuroprotective function of deep mind stimulation, antiglutamatergic remedy and apomorphine may be tested in medical reports within the close to destiny. this is often additionally the case for destiny healing methods to recovery of the broken fearful method, equivalent to somatic gene remedy, implantation of genetically converted cell-lines and medically managed and directed improvement of embryonic cells. The convention highlighted the position of the glia, which turns out to play a key position, either in commonly as neuroimmunological and neurodegenerative problems categorized ailments, as indicated above. the subjects mentioned within the publication are major for fresh advancements in scientific neurology and neuroscience, as proven within the present literature and at overseas congresses.

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Pramipexole and ropinirole appear to be quite close drugs. Both are selective non ergot D2 (and preferentially D3) agonists, with an elimination half-life of 5 to 10 hours. Conversely, cabergoline is an ergot derivative, less selective for the D2 receptors, with a much longer elimination half-life (60 hours or more). In moderately advanced levodopa treated patients with Parkinson's disease and motor fluctuations, cabergoline, pramipexole and ropinirole all do significantly better than placebo in reducing UPDRS motor examination scores, time spent off and daily dose of levodopa.

Cabergoline is an ergot derivative, with its consequent effects on nondopamine receptors, and has the longest elimination half-life (more than 60 years). These 3 "new" dopamine agonists, can reduce L-dopa daily dose, can reduce the percentage of time spent off and can improve UPDRS scores in moderately advanced fluctuating patients with Parkinson's disease. This is achieved, however, with no clear superiority over bromocriptine, and there is no clinical evidence that these new agents have significant distinctive efficacy or adverse events profiles.

Rascol Department of Clinical Pharmacology, INSERM U455 and Clinical Investigation Center, University Hospital, Toulouse, France Summary. Three new dopamine agonists (cabergoline, pramipexole, ropinirole) have been put on to the market within the past months to treat patients with Parkinson's disease. Like any marketed dopamine agonists, the new compounds bind to the D2-like receptors. Pramipexole and ropinirole appear to be quite close drugs. Both are selective non ergot D2 (and preferentially D3) agonists, with an elimination half-life of 5 to 10 hours.

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